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Nutrition Bulletin from The Renaisanté Institue of Integrative Medicine

- by Dr. James Meschino, DC, MS, ROHP

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Antioxidants and Alzheimer’s Disease


Chicago Health in Aging Project

The average annual decline in cognitive score was 34% less in those with the highest Vitamin E intake (mean of 299 I.U./day) compared with those in the lowest intake group (6.7 I.U./day.) A weak association was also seen for Vitamin C. (n=6,000 persons aged 62-102 years followed for 3 years.) – Morris, M.C., et al, 2000.


Rotterdam Study

Those who did not develop Alzheimer’s disease or vascular dementia consumed higher amounts of foods (especially vegetables) containing Vitamin E, Beta-carotene and Vitamin C. (n=5,395 persons aged 55 years and older followed for 6 years.) – Engelhart, M..J., et al, 2000


Vitamin E

inhibits Abeta-associated free radical oxidative stress in the cortical synaptosomal membranes and hippocampal neuronal cells in culture. “Taken together with the recent report that Vitamin E slows the progression of Alzheimer’s disease, this review strongly supports a central role of Abeta-associated free radical oxidative stress in neurotoxicity in Alzheimers’ disease brain.” – Butterfield, D.A., et al, 1999.


Alzheimer’s Disease Co-operative Study

Alzheimer’s patients with moderately advanced disease were treated with 2,000 I.U. Vitamin E/day. The results indicated that Vitamin E slows functional deterioration leading to nursing home placement and retards the progression of the disease. – Grundman, M., 2000.


Free radical oxidative stress is now strongly linked to the development of dementia and Alzheimer’s disease. Evidence is accumulating to demonstrate that individuals with superior antioxidant defenses are at less risk, regardless of genetic susceptibility for this disease. Additionally, a number of studies link sub-optimal B-vitamin status (B6, B12, folic acid) with increased risk of dementia and loss of cognitive function.

Ensuring optimal intake of B-vitamins (B-complex 50) and antioxidants throughout one’s lifetime may be an important wellness strategy to help prevent Alzheimer’s disease and decline in cognitive abilities. Approximately 6-8% of all persons aged >65 have Alzheimer’s disease and the prevalence of the disease is increasing. The current research lends further support to the use of an antioxidant and B-vitamin enriched daily dietary supplement to help support brain function as we age.

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Nutrition Bulletin From The Renaisanté Institue Of Integrative Medicine

Dr. James Meschino, 


Global Integrative Medicine Academy

The Global Integrative Medicine Academy was created to satisfy a need, expressed by many health professionals, to establish credentials as experts in Nutritional Medicine. But, health professionals also needed to be able to complete the programme with a minimum impact on their career, family, and lifestyle. That is why the Advanced Nutritional Medicine and Sports Nutrition Certification Program was created.